protein

Plasma kallikrein/KLKB1 Protein, Human (HEK293, His)

HY-P70249A

20 μg;50 μg;100 μg

235;520;884 USD

Plasma kallikrein/KLKB1 Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

235;520;884 USD

Plasma kallikrein (KLKB1) serves as an enzyme, cleaving Lys-Arg and Arg-Ser bonds to release bradykinin from HMW kininogen. It plays a crucial role in the reciprocal activation of factor XII, especially upon binding to a negatively charged surface. Besides its role in the kinin system, KLKB1 may contribute to the renin-angiotensin system by converting prorenin into renin. Plasma kallikrein/KLKB1 Protein, Human (HEK293, His) is the recombinant human-derived Plasma kallikrein/KLKB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Plasma kallikrein/KLKB1 Protein, Human (HEK293, His) is 619 a.a., with molecular weight of 72-80 kDa.

Human

Plasma kallikrein (KLKB1) is an enzyme with the ability to cleave Lys-Arg and Arg-Ser bonds, facilitating the release of bradykinin from HMW kininogen. Additionally, KLKB1 plays a pivotal role in the activation of factor XII through a reciprocal reaction, particularly following its binding to a negatively charged surface. Beyond its involvement in the kinin system, this enzyme may contribute to the renin-angiotensin system by converting prorenin into renin.

Plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in 20 mM NaAc,150 mM NaCl, pH 5.0. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.