protein

Ferritin light chain/FTL Protein, Human (His)

HY-P70245

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

35;45;100;170;480;800 USD

Ferritin light chain/FTL Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

35;45;100;170;480;800 USD

Ferritin light chain/FTL protein is pivotal in iron homeostasis, storing iron in a soluble, non-toxic form and delivering it to cells. In kidney development, FTL mediates iron uptake in capsule cells, crucial for organogenesis. Structurally, FTL, an oligomer with light and heavy subunits forming a spherical shell, facilitates iron entry through pores. Mutations in the C-terminus disrupt pore formation, impacting iron accumulation. Ferritin light chain/FTL Protein, Human (His) is the recombinant human-derived Ferritin light chain/FTL protein, expressed by E. coli , with N-6*His labeled tag. The total length of Ferritin light chain/FTL Protein, Human (His) is 175 a.a., with molecular weight of 20-25 kDa.

Human

Ferritin light chain/FTL protein plays a pivotal role in iron homeostasis by storing iron in a soluble, non-toxic, and readily available form. The ferrous iron is taken up and subsequently deposited as ferric hydroxides after oxidation. Beyond its iron storage function, FTL is actively involved in delivering iron to cells, underscoring its significance in cellular processes. In the context of kidney development, FTL participates in mediating iron uptake in capsule cells, highlighting its role in organogenesis. Structurally, FTL exists as an oligomer comprising 24 subunits, with two types of subunits, light (L) and heavy (H), forming the spherical shell. The functional molecule features a central cavity where the insoluble mineral iron core is deposited. This intricate structure allows iron entry through pores formed between subunits. Mutations affecting the C-terminus can interfere with normal pore formation and disrupt iron accumulation.

rHuFerritin light chain/FTL, His; Ferritin L subunit; Ferritin light chain; FTL

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 250 mM NaCl, 1 mM EDTA, pH 9.5. Or lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 200 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.