protein

IFN-alpha 1/IFNA13 Protein, Human (HEK293, His)

HY-P70241

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

54;150;420;720;1500;2200 USD

IFN-alpha 1/IFNA13 Protein, Human (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg;1 mg

54;150;420;720;1500;2200 USD

IFN-alpha 1 (IFNA1), belongs to type I interferon family, is produced by macrophages with antiviral activities [1] . IFN-alpha 1 involves in the activation of JAK1 and TYK2 pathway [4] , exerts function by inhibiting viral replication as well as modulating immune response [3] . IFN-alpha 1/IFNA13 Protein, Human (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag.

Human

IFN-alpha 1 (IFNA1; IFN-α1), belongs to the alpha/beta interferon family, is produced by macrophages with antiviral activities [1] . Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . IFNs binds to one of three type-specific receptors, which leads to the activation of JAK1 and TYK2 [3] . This signal transduction results in phosphorylation of STAT1 and STAT2 and eventually in an association with IFN regulatory factor 9 (IRF9) and formation of the IFN-stimulated gene factor 3 (ISGF3) complex. Thus the ISGF3 complex induces transcription of IFN-stimulated genes (ISGs), with subsequent immunomodulatory effects on both innate and adaptive immune responses [4] . The interactions of type I IFN with the immune system is important for the generation of a durable antitumor response through its effects on dendritic cells (DC) [5] . IFN has been widely used for animal disease model, and the sequence of amino acids in IFNA1 protein of human is very different from mouse (62.96%).

rHuInterferon alpha-1, His; Interferon alpha-1/13; IFN-alpha-1/13; Interferon alpha-D; LeIF D; IFNA1; IFNA13

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.