protein

OPRD1 Protein, Human (Cell-Free, His)

HY-P702402

20 μg;50 μg;100 μg

380;720;1150 USD

OPRD1 Protein, Human (Cell-Free, His)

proteins

E. coli Cell-free

20 μg;50 μg;100 μg

380;720;1150 USD

The OPRD1 protein is a G protein-coupled receptor for enkephalins and opioids that undergoes ligand-induced conformational changes to activate signaling through G proteins and inhibit adenylate cyclase. Additionally, it reduces neurotransmitter release by affecting ionic currents. OPRD1 Protein, Human (Cell-Free, His) is the recombinant human-derived OPRD1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of OPRD1 Protein, Human (Cell-Free, His) is 372 a.a., with molecular weight of 41.9 kDa.

Human

The OPRD1 Protein, a G-protein coupled receptor, serves as a receptor for endogenous enkephalins and a subset of other opioids. Upon ligand binding, the receptor undergoes a conformational change, initiating signaling via guanine nucleotide-binding proteins (G proteins) and modulating downstream effectors like adenylate cyclase, resulting in the inhibition of adenylate cyclase activity. Additionally, OPRD1 inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Crucially, it plays a pivotal role in the perception of pain and opiate-mediated analgesia, contributing to the development of analgesic tolerance to morphine. OPRD1 may form homooligomers and forms a heterodimer with OPRM1, interacting with GPRASP1 and RTP4 to regulate cell surface localization of the OPRD1-OPRM1 heterodimer. These interactions highlight the complex regulatory mechanisms through which OPRD1 modulates opioid signaling and analgesic responses.

Delta-type opioid receptor; D-OR-1; DOR-1

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution PBS, 0.05% Brij-78, 6%Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.