protein

GLP-1/GCG Protein, Human (HEK293, His)

HY-P70239

10 μg;50 μg;100 μg

160;450;720 USD

GLP-1/GCG Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg;100 μg

160;450;720 USD

GLP-1 and GCG are two proteins derived from the same precursor protein, which is encoded by the GCG-glucagon gene. The GCG protein is a counterregulatory hormone to insulin, playing a crucial role in glucose metabolism by increasing gluconeogenesis and reducing glycolysis to regulate blood glucose levels. GLP-1 protein, secreted by intestinal endocrine cells, promotes insulin secretion, regulates gastrointestinal motility, and inhibits the secretion of GCG protein. GLP-1/GCG protein, Human (HEK293, His), is a recombinant GLP-1/GCG protein expressed by HEK293 cells, with a His tag at the C-terminus, and is composed of 160 amino acids (R21-K180) [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] .

Human

GCG protein, also known as glucagon, is secreted by pancreatic α-cells and plays an important role in glucose metabolism and homeostasis. As a counterregulatory hormone to insulin, GCG protein counteracts the glucose-lowering effects of insulin when blood glucose levels drop, helping to maintain glucose balance in the body by raising blood sugar levels. In diabetes, GCG protein plays a key role in initiating and maintaining hyperglycemic conditions. Beyond regulating glucose metabolism, GCG protein also participates in lipid metabolism regulation [1] [2] [3] . GLP-1 protein is a hormone secreted by the intestine, and it plays a significant role in regulating blood glucose levels and maintaining gastrointestinal function. Blood Glucose Regulation: GLP-1 protein enhances the glucose sensitivity of pancreatic β-cells by binding to receptors on their surface, leading to increased insulin secretion when blood glucose levels are high. Additionally, GLP-1 protein can promote the regeneration of islet cells and the proliferation of pancreatic β-cells, while possibly inhibiting β-cell apoptosis, thereby protecting islet function [4] . Gastrointestinal Function: GLP-1 protein helps maintain normal gastrointestinal function by inhibiting the secretion of GCG protein. It also enhances the uptake, utilization, and storage of glucose in peripheral tissues by regulating satiety. Moreover, GLP-1 protein promotes the growth of intestinal epithelium, contributing to intestinal health [5] . In addition, GLP-1 protein can regulate the hypothalamic-pituitary axis (HPA) by influencing the secretion of LH, TSH, CRH, oxytocin, and antidiuretic hormone [5] . Anti-inflammatory Effects: GLP-1 protein has anti-inflammatory effects on the islets and adipose tissues by reducing the production of inflammatory cytokines and the infiltration of immune cells into tissues. Furthermore, GLP-1 protein has shown anti-inflammatory effects in various chronic inflammatory diseases, including type 1 and type 2 diabetes, atherosclerosis, neurodegenerative diseases, non-alcoholic fatty liver disease, and diabetic nephropathy [6] .

rHuPro-glucagon/GCG, His ; Glucagon; Glicentin; Glicentin-Related Polypeptide; GRPP; Oxyntomodulin; OXM; OXY; Glucagon; Glucagon-Like Peptide 1; GLP-1; Incretin Hormone; Glucagon-like Peptide 1; GLP-1; Glucagon-Like Peptide 2; GLP-2; GCG

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 1 mM DTT, 50% Glycerol, pH 8.0.

Shipping with dry ice