protein

MFN2 Protein, Human (Cell-Free, His)

HY-P702377

20 μg;50 μg

990;1600 USD

MFN2 Protein, Human (Cell-Free, His)

proteins

E. coli Cell-free

20 μg;50 μg

990;1600 USD

MFN2 is a mitochondrial outer membrane GTPase that regulates mitochondrial dynamics, balancing fusion and fission to achieve dynamic organelle morphology. Its overexpression forms an extensive mitochondrial network, highlighting its organizational role. MFN2 Protein, Human (Cell-Free, His) is the recombinant human-derived MFN2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of MFN2 Protein, Human (Cell-Free, His) is 757 a.a., with molecular weight of 87.9 kDa.

Human

MFN2, a mitochondrial outer membrane GTPase, intricately governs mitochondrial dynamics by mediating both clustering and fusion processes. This GTPase orchestrates the equilibrium between mitochondrial fusion and fission, critically shaping the dynamic morphology of these organelles. Notably, its overexpression induces the formation of extensive mitochondrial networks, emphasizing its pivotal role in mitochondrial organization. The GTPase activity of MFN2 is essential for membrane clustering and may involve significant rearrangements in the coiled coil domains. Beyond its structural contributions, MFN2 emerges as a central player in mitochondrial metabolism, implicating its association with obesity and apoptosis processes. Furthermore, it regulates vascular smooth muscle cell proliferation, demonstrating its diverse roles in cellular functions. In the realm of mitochondrial quality control, MFN2 is instrumental in clearing damaged mitochondria through selective autophagy (mitophagy) by facilitating the recruitment of PRKN to dysfunctional mitochondria. Additionally, it plays a crucial role in modulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, acting as an upstream regulator of EIF2AK3 and suppressing its activation under basal conditions. This multifaceted functionality underscores the significance of MFN2 in cellular homeostasis and stress response mechanisms.

Mitofusin-2; Transmembrane GTPase MFN2

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, 0.05% Brij-78, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.