protein

FSH Protein, Human (HEK293, Flag-His)

HY-P70237

2 μg;10 μg;50 μg

60;170;510 USD

FSH Protein, Human (HEK293, Flag-His)

proteins

HEK293

2 μg;10 μg;50 μg

60;170;510 USD

Follicle-stimulating hormone (FSH) is a glycoprotein dimer polypeptide hormone produced by the anterior pituitary in response to gonadotropin-releasing hormone (GnRH) from the hypothalamus, which consists of Glycoprotein hormones α chain and Follitropin subunit β. FSH binds to FSHR , a G protein-coupled receptor, on target cells to activate downstream signaling pathways. FSH is involved in follicle development and spermatogenesis in reproductive organs. FSH Protein, Human (HEK293, Flag-His) is a recombinant protein with a Flag-His label that consisting of 116 amino acids of Glycoprotein hormones α chain and 129 amino acids of Follitropin subunit β, which is expressed in HEK293 cells [1] [2] [3] [4] [5] [6] [7] [8] [9] .

Human

FSH Protein (Human) is a glycoprotein dimer with α and β subunits. The β subunit is unique to FSH, while the α subunit is shared as same as in thyroid stimulating hormone (TSH), choriogonadotropin (CG) and luteinizing hormone (LH) [1] . Follicle growth is directly dependent on FSH Protein (Human) stimulation. Granulosa cells from small follicles express FSH Protein (Human) receptors and respond to FSH Protein (Human) stimulation by synthesizing aromatase [1] . FSH Protein (Human) release is stimulated by gonadotropin-releasing hormone (GnRH): The hypothalamus produces GnRH, and it is released into the hypophyseal portal circulation to act on G-protein-coupled receptors at gonadotropic cells of the anterior pituitary. Gonadotropic cells produce FSH and luteinizing hormone (LH) and release them into the peripheral circulation [4] . FSH Protein (Human) regulates the development, growth, pubertal maturation and reproductive processes of the human body. FSH Protein (Human) is used commonly in infertility therapy, mainly for ovarian hyperstimulation. In some cases, it is used in ovulation induction for reversal of anovulation as well [5] . FSH Protein (Human) secretion is inhibited by negative feedback from estrogen levels in women and FSH Protein (Human) secretion is inhibited by levels of inhibin B (secreted by the Sertoli cells) via negative feedback in men [5,6] . FSH Protein (Human) Levels are associated with various diseases, such as Polycystic Ovarian Syndrome, male infertility, hypogonadotropic hypogonadism, Kallman Syndrome, Turner Syndrome, pituitary adenomas, and more [1,7,8,9] .

rHuFollicle-stimulating hormone/FSH, Flag-His; Follicle-stimulating hormone; FSH; FSH alpha/beta

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.