protein

Haptoglobin Protein, Human (HEK293, His)

HY-P70230

10 μg;50 μg

160;450 USD

Haptoglobin Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

160;450 USD

Haptoglobin captures and binds free plasma hemoglobin, preventing kidney damage and promoting hepatic recycling of heme iron. It acts as an antioxidant, exhibits antibacterial activity, and modulates various aspects of the acute phase response. Haptoglobin Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Haptoglobin protein, expressed by HEK293 , with C-6*His labeled tag. Haptoglobin Protein, Human (HEK293, His), has molecular weight of 16 & 40-75 kDa, respectively.

Human

The Haptoglobin protein functions to capture and bind free plasma hemoglobin, preventing kidney damage and enabling hepatic recycling of heme iron. During hemolysis, hemoglobin can accumulate in the kidneys and be secreted in urine. Additionally, Haptoglobin acts as an antioxidant, exhibits antibacterial activity, and plays a role in modulating various aspects of the acute phase response. The complexes formed between hemoglobin and Haptoglobin are efficiently cleared by the macrophage CD163 scavenger receptor on liver Kupfer cells through an endocytic lysosomal degradation pathway. Notably, the uncleaved form of the alpha-2 allele (2-2), known as zonulin, has implications in intestinal permeability by regulating intercellular tight junction disassembly and influencing the balance between tolerance and immunity to non-self antigens.

rHuHaptoglobin/HP, His; Haptoglobin; Zonulin; HP

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.