protein

IFN-alpha 2b/IFNA2 Protein, Human

HY-P7023

2 μg;10 μg;50 μg;100 μg

35;60;120;170 USD

IFN-alpha 2b/IFNA2 Protein, Human

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

35;60;120;170 USD

375588473

IFN-alpha 2 (IFNA2), belongs to type I interferon family, is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection [1] . IFN-alpha 2 exerts cytotoxic activity against CD8 + T cells and induces CD4 + T cell depletion [3] . IFN-alpha 2b/IFNA2 Protein, Human contains 165 a.a. (C24-E188), is a protein produced in E. coli with tag free.

Human

IFN-alpha 2 (IFNA2; IFN-α2), belongs to the type I interferon family, produced by the plasmacytoid dendritic cells (pDCs) exposure to HIV-1BaL in order to inhibit viral infection [1] . Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . IFN-alpha 2 subtype is the only one that is currently licensed to treat infections caused by hepatitis B virus (HBV) and HCV [3] . IFN-alpha 2 shows a Sortilin-dependent trafficking in cells and increases the expression level of interferon-stimulated genes (ISGs) in HIV-infected cells [1] [4] . It also exhibits cytotoxic activity against CD8 + T cells and enhances CD4 + T cell depletion [3] . Among the IFN-alpha 2 alleles, IFN-alpha 2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant [5] . IFN-alpha 2 has a bored application in research of cancer, including some hematological malignancies and solid tumors [6] .

rHuIFN-α2b; IFNA; INFA2; IFN-a 2b

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.2.

Room temperature in continental US; may vary elsewhere.