product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
CD9 Protein, Mouse (Cell-Free, His)
catalog :
HY-P702243
quantity :
20 μg;50 μg
price :
500;1000 USD
product information
Catalog Number :
HY-P702243
Product Name :
CD9 Protein, Mouse (Cell-Free, His)
Product Type :
proteins
Host Species :
E. coli Cell-free
Size :
20 μg;50 μg
List Price :
500;1000 USD
Product Description :
The CD9 protein is an integrin-linked integral membrane protein that regulates sperm-egg fusion, platelet activation, and cell adhesion. On oocytes, it promotes sperm-egg fusion by organizing multi-protein complexes. CD9 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived CD9 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CD9 Protein, Mouse (Cell-Free, His) is 226 a.a., with molecular weight of 28.1 kDa.
SpeciesSummary :
Mouse
Background :
The CD9 protein, an integral membrane protein associated with integrins, plays a pivotal role in regulating various processes, including sperm-egg fusion, platelet activation and aggregation, and cell adhesion. It is prominently present on the cell surface of oocytes, where it assumes a key role in sperm-egg fusion, potentially by orchestrating multiprotein complexes and influencing membrane morphology essential for the fusion process. In myoblasts, CD9 associates with CD81 and PTGFRN, acting as an inhibitor of myotube fusion during muscle regeneration. Within macrophages, CD9 forms associations with CD9 and beta-1 and beta-2 integrins, preventing macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles and impeding the fusion between mononuclear cell progenitors into osteoclasts responsible for bone resorption. CD9 also acts as a receptor for PSG17 and is involved in platelet activation and aggregation, regulating paranodal junction formation. Its role extends to cell adhesion, cell motility, and tumor metastasis, particularly influencing integrin-dependent migration of macrophages, a critical aspect of the inflammatory response in the lung. CD9 forms disulfide-linked homodimers, higher homooligomers, and heterooligomers with other tetraspanin family members. It interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB1, forming complexes with CD81, beta-1, and beta-2 integrins, CD63, CR2/CD21, PTGFRN/CD9P1, and IGSF8, the latter interaction being direct. Additionally, CD9's interaction with PDPN is homophilic and attenuates platelet aggregation and pulmonary metastasis induced by PDPN.
ALTnames :
CD9 antigen
Purity :
Greater than 90% as determined by reducing SDS-PAGE.
Buffer :
Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.15 M NaCl, 0.05% Brij78, 6% Trehalose, pH 8.0.
Storage :
Room temperature in continental US; may vary elsewhere.
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com
609-228-6898
headquarters: USA