protein

AQP4 Protein, Mouse (Cell-Free, His)

HY-P702216

20 μg;50 μg

950;1800 USD

AQP4 Protein, Mouse (Cell-Free, His)

proteins

E. coli Cell-free

20 μg;50 μg

950;1800 USD

The AQP4 protein forms water-specific channels that are critical for brain water homeostasis and lymphoid solute transport. It regulates water exchange at the blood-brain interface, promoting the influx of cerebrospinal fluid into the brain and the drainage of interstitial fluid. AQP4 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived AQP4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of AQP4 Protein, Mouse (Cell-Free, His) is 323 a.a., with molecular weight of 40.5 kDa.

Mouse

AQP4 Protein forms a water-specific channel, crucial for brain water homeostasis and glymphatic solute transport. It plays a vital role in the normal rate of water exchange across the blood-brain interface and is necessary for cerebrospinal fluid influx into the brain cortex and parenchyma, along with drainage of interstitial fluid. AQP4 is essential for the clearance of solutes, including soluble beta-amyloid peptides, from the brain interstitial fluid. Additionally, it plays a redundant role in urinary water homeostasis and concentrating ability. Existing as a homotetramer, AQP4 tetramers can create oligomeric arrays in membranes, with varying sizes between tissues. Interactions among AQP4 oligomeric arrays in adjacent cells contribute to cell-cell adhesion, and it is part of a complex containing MLC1, TRPV4, HEPACAM, and ATP1B1.

Aquaporin-4; Mercurial-insensitive water channel; MIWC; WCH4

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.15 M NaCl, 0.05% Brij-78, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.