protein

ADRB2 Protein, Human (Cell-Free, His, SUMO)

HY-P702206

10 μg;50 μg;100 μg

385;1000;1600 USD

ADRB2 Protein, Human (Cell-Free, His, SUMO)

proteins

E. coli Cell-free

10 μg;50 μg;100 μg

385;1000;1600 USD

ADRB2 protein is an important member of the β-adrenergic receptor family and mediates catecholamine-induced adenylyl cyclase activation through G protein action. It has 30 times greater affinity for epinephrine and plays a crucial role in cellular responses to sympathetic nervous system stimulation. ADRB2 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived ADRB2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag and G16R, E27Q mutation. The total length of ADRB2 Protein, Human (Cell-Free, His, SUMO) is 413 a.a., with molecular weight of 65 kDa.

Human

The ADRB2 Protein, belonging to the beta-adrenergic receptor family, plays a pivotal role in mediating catecholamine-induced activation of adenylate cyclase through G protein action. With approximately 30-fold higher affinity for epinephrine compared to norepinephrine, ADRB2 is a key player in cellular responses to sympathetic nervous system stimulation. The protein engages in various molecular interactions, binding to NHERF1, GPRASP1, ARRB1, ARRB2, SRC, USP20, USP33, VHL, EGLN3, SNX27, CNIH4, ARRDC3, NEDD4, and MARCHF2. These interactions contribute to the intricate regulation of ADRB2 function, including its ubiquitination, degradation, and recycling processes, underscoring its importance in modulating cellular responses to adrenergic signaling.

Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.15 M NaCl, 0.05% FOS12, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.