protein

MPZL1 Protein, Human (HEK293, His)

HY-P70220

10 μg;50 μg

50;105 USD

MPZL1 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

50;105 USD

MPZL1 protein is a cell surface receptor that participates in signal transduction by recruiting PTPN11/SHP-2 to the cell membrane. MPZL1 Protein, Human (HEK293, His) is the recombinant human-derived MPZL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MPZL1 Protein, Human (HEK293, His) is 127 a.a., with molecular weight of 20-28 kDa.

Human

MPZL1, a cell surface receptor intricately involved in signal transduction processes, plays a pivotal role in recruiting PTPN11/SHP-2 to the cell membrane, establishing itself as a putative substrate for PTPN11/SHP-2. As a major receptor for concanavalin-A (ConA), MPZL1 contributes to cellular signaling induced by ConA, likely involving Src family tyrosine-protein kinases. The isoform 3 variant appears to exert a dominant negative effect, inhibiting the tyrosine phosphorylation of MPZL1 induced by ConA. Notably, isoform 1, distinct from isoform 2 and isoform 3, is implicated in the regulation of integrin-mediated cell motility. The receptor also engages in interactions with phosphorylated PTPN11/SHP-2, underscoring its multifaceted involvement in signal transduction cascades.

rHuMyelin protein zero-like protein 1/MPZL1, His; Myelin protein zero-like 1; isoform CRA_b; cDNA FLJ78597; highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1); transcript variant 1; mRNA ; cDNA; FLJ96614; Homo sapiens myelin protein zero-like 1 (MPZL1); Mrna

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.