protein

IGFBP-5 Protein, Human

HY-P7021

10 μg;50 μg

160;450 USD

IGFBP-5 Protein, Human

proteins

CHO

10 μg;50 μg

160;450 USD

375588471

IGFBP-5 Protein, Human is a unique insulin-like growth factor-binding protein, modulates the actions of secreted insulin-like growth factors, and stimulates osteoblast proliferation.

Human

Insulin-like Growth Factor-Binding Proteins (IGFBPs) modulate the actions of secreted insulin-like growth facts (IGFs) by binding to them and increase the IGF halflife in the extracellular milieu and circulation by sequestering them in this bound form. IGFBPs either enhance or inhibit IGF actions on target cells; the individual IGFBPs either inhibit or potentiate IGF effects on osteoblasts in bone. Human Insulin-like Growth Factor-Binding Protein 5 (rhIGFBP-5) is a unique and most abundant IGFBP stored in bone, having a high specific binding affinity for hydroxyapatite and extracellular matrix proteins, therefore fixing it and its bound IGFs within bone. rhIGFBP-5 consistently stimulates osteoblast cell proliferation in vitro, thus increasing the number of osteoblasts [1] .

rHuIGF-BP5; IBP-5

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 20 mM PB, 150mM NaCl, pH7.4.

Room temperature in continental US; may vary elsewhere.