protein

IGFBP-3 Protein, Human

HY-P7020

10 μg;50 μg

125;350 USD

IGFBP-3 Protein, Human

proteins

E. coli

10 μg;50 μg

125;350 USD

375588470

IGFBP-3 Protein, Human belongs to insulin-like growth factor-binding protein, prolongs the half-life of the insulin-like growth factors (IGFs), inhibits interaction of IGFs with their cell surface receptors, and functions in cancer reduction.

Human

Insulin-like Growth Factor-Binding Proteins (IGFBPs) modulate the actions of secreted insulin-like growth facts (IGFs) by binding to them and increase the IGF halflife in the extracellular milieu and circulation by sequestering them in this bound form. IGFBPs either enhance or inhibit IGF actions on target cells; the individual IGFBPs either inhibit or potentiate IGF effects on osteoblasts in bone [1] . Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) is involved in prolonging the half-life of the IGFs (from 12 minutes to 12 hours), inhibits interaction of IGFs with their cell surface receptors, as well as, it is a circulating reservoir of IGFs. Moreover, IGFBP3 functions in cancer reduction, by both IGF-dependent and IGF-independent mechanisms. IGFBP3 has been shown to reduce the risk of breast cancer in high doses. A high concentration of IGFBP3 prevents IGF1:IGF1R interaction and blocks the IGF1R tyrosine kinase activity, resulting in the inhibition of the formation of intracellular signaling cascades [2] .

rHuIGF-BP3; IBP-3; IGF-binding protein 3; IGFBP-3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.