product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
MCD Protein, Human (His)
catalog :
HY-P701982
quantity :
10 μg;50 μg
price :
165;425 USD
product information
Catalog Number :
HY-P701982
Product Name :
MCD Protein, Human (His)
Product Type :
proteins
Host Species :
E. coli
Size :
10 μg;50 μg
List Price :
165;425 USD
Product Description :
MCD proteins catalyze the conversion of malonyl-CoA to acetyl-CoA, ensuring that only methylmalonyl-CoA serves as a substrate for fatty acid synthase, producing fatty acids with multiple methyl side chains. MCD Protein, Human (His) is the recombinant human-derived MCD protein, expressed by E. coli , with N-6*His labeled tag. The total length of MCD Protein, Human (His) is 452 a.a., .
SpeciesSummary :
Human
Background :
The MCD protein plays a pivotal role in cellular metabolism by catalyzing the conversion of malonyl-CoA to acetyl-CoA. Particularly significant in fatty acid biosynthesis, MCD selectively eliminates malonyl-CoA, ensuring that methyl-malonyl-CoA becomes the exclusive substrate for fatty acid synthase. This selective removal mechanism contributes to the production of fatty acids with multiple methyl side chains. In peroxisomes, MCD is implicated in the degradation of intraperoxisomal malonyl-CoA, a byproduct of peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Beyond its involvement in lipid metabolism, MCD influences the metabolic balance between glucose and lipid oxidation in muscle, independent of insulin signaling alterations. Additionally, MCD may play a role in mitigating ischemic injury by promoting glucose oxidation, highlighting its multifaceted impact on cellular functions and metabolic pathways.
ALTnames :
MLYCD; Malonyl-CoA decarboxylase; mitochondrial; MCD
Purity :
Greater than 90% as determined by reducing SDS-PAGE.
Buffer :
Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 200 mM NaCl, 20% glycerol, 1 mM DTT.
Storage :
Shipping with dry ice
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com
609-228-6898
headquarters: USA