protein

Neuropilin-1 Protein, Cynomolgus (HEK293, His)

HY-P70185

10 μg;50 μg

80;240 USD

Neuropilin-1 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

10 μg;50 μg

80;240 USD

Neuropilin-1 Protein, a transmembrane glycoprotein, regulates axon guidance, angiogenesis, neuronal development, and immune responses. Neuropilin-1 can interacts with VEGF and semaphorins, and promote the growth, survival, and self-renewal of tumors. Neuropilin-1 also acts as an entry factor and potentiate SARS-CoV-2 and Epstein-Barr virus (EBV) infectivity. Furthermore, Neuropilin-1 acts as a co-receptor for TGF-β, and enhances TGF-β activity via the SMAD2/3 signaling pathway [1] [2] [3] . Neuropilin-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Cynomolgus

Neuropilin-1 (NRP1) protein is a transmembrane glycoprotein. In mice, NRP1 is selectively expressed on thymic-derived Tregs, and enhances immunosuppressive function. In humans, NRP1 is mainly expressed on plasmacytoid dendritic cells (pDCs) where it aids in priming immune responses, as well as on a subset of T regulatory cells (Tregs) isolated from secondary lymph nodes [1] . Neuropilin-1 transduce signals for VEGFs, together with VEGFR family members. Neuropilin-1 interacts with VEGF and semaphorins, and can promote the growth, survival, and self-renewal of tumors. For example, Neuropilin-1 can complex with VEGFR2 in vascular endothelial cells to induce vessel permeability and angiogenesis [3] . Neuropilin-1 also acts as an entry factor and potentiate SARS-CoV-2 infectivity. Besides, Neuropilin-1 is an entry receptor for Epstein-Barr virus (EBV) infection of nasopharyngeal epithelial cells, and enhances EBV infection [2] [3] . NRP-1 plays a central role in axonal guidance and pruning by interaction with Semaphorin-3A (a protein seen widely in both the nervous system and the vasculature) [3] . Furthermore, Neuropilin-1 acts as a co-receptor for TGF-β, and enhances TGF-β activity via the SMAD2/3 signaling pathway. Neuropilin-1 can activate the inactive latent form (LAP-TGF-β), and also promote immune suppression [1] . Neuropilin-1 plays an important role in angiogenesis, neuronal development, and the regulation of immune responses.

rCynNeuropilin-1, His; CD304; NRP1; NRPNP1; VEGF165R; BDCA4; Neuropilin-1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.