protein

RIOK2 Protein, Human (Sf9, His, GST)

HY-P701766

10 μg;50 μg

320;900 USD

RIOK2 Protein, Human (Sf9, His, GST)

proteins

Sf9 insect cells

10 μg;50 μg

320;900 USD

RIOK2 is an important serine/threonine protein kinase that is critical in the final cytoplasmic maturation phase of the 40S ribosomal subunit. It promotes the export of 40S preribosomal particles from the nucleus to the cytoplasm, which is essential for ribosome biogenesis. RIOK2 Protein, Human (Sf9, His, GST) is the recombinant human-derived RIOK2 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of RIOK2 Protein, Human (Sf9, His, GST) is 551 a.a., .

Human

RIOK2, a serine/threonine-protein kinase, plays a pivotal role in the final stages of cytoplasmic maturation of the 40S ribosomal subunit. Its involvement extends to the export of pre-40S ribosome particles from the nucleus to the cytoplasm, a crucial step in ribosomal biogenesis. The kinase activity of RIOK2 is essential for orchestrating the release of NOB1, PNO1, and LTV1 from the late pre-40S subunit and facilitating the processing of 18S-E pre-rRNA into mature 18S rRNA. Beyond its role in ribosome maturation, RIOK2 exhibits regulatory functions in the cell cycle, specifically influencing the timing of the metaphase-anaphase transition during mitotic progression. This regulatory role is likely modulated by phosphorylation, possibly by PLK1, highlighting the multifaceted contributions of RIOK2 to cellular processes.

RIOK2; Serine/threonine-protein kinase RIO2; RIO kinase 2

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50mM HEPES (pH 7.5), 200mM NaCl, 10% glycerol, 5mM DTT, 0.1M Trehalose.

Shipping with dry ice