protein

LRG1 Protein, Human (HEK293, Fc-His)

HY-P70175

10 μg;50 μg

115;345 USD

LRG1 Protein, Human (HEK293, Fc-His)

proteins

HEK293

10 μg;50 μg

115;345 USD

Leucine-rich alpha-2-glycoprotein (encoded by LRG1) is a serum biomarkerof inflammatory bowel disease and various autoimmune diseases. LRG1 can bind to TGF-β1 (K D : 2.32 µM) and modulate the TGFβ pathway [1] [2] [3] . LRG1 Protein, Human (HEK293, Fc-His) is the recombinant human-derived LRG1 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.

Human

Leucine-rich alpha-2-glycoprotein (encoded by LRG1), an approximately 50 kDa glycoprotein, is a serum biomarkerof inflammatory bowel disease and various autoimmune diseases. LRG1 can bind to TGF-β1 (K D : 2.32 µM) and modulate the TGFβ pathway, and promotes ECM integrity by activating the TGF-beta signaling pathway in fibroblasts [1] . LRG1 is usually secreted by neutrophils undergoing differentiation and by liver cells [2] . Besides, LRG1 enhances TGFβ1-smad1/5/8 signaling in the presence of endoglin in endothelial cells. LRG1 also promotes TGFβ1-induced apoptosis [3] .

rHuLeucine-rich alpha-2-glycoprotein/LRG1, Fc-His; Leucine-rich alpha-2-glycoprotein; LRG and LRG1

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 200 mM NaCl, 10% Glycerol, pH 8.0.

Shipping with dry ice.