product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
PIM1 Protein, Human
catalog :
HY-P701745
quantity :
10 μg;50 μg
price :
220;620 USD
more info or order :
product information
Catalog Number :
HY-P701745
Product Name :
PIM1 Protein, Human
Product Type :
proteins
Host Species :
E. coli
Size :
10 μg;50 μg
List Price :
220;620 USD
Product Description :
The PIM1 protein is a proto-oncogene with serine/threonine kinase activity that significantly promotes cell survival and proliferation, providing a selective advantage for tumorigenesis. It regulates MYC transcription, cell cycle progression, and inhibits pro-apoptotic proteins such as BAD, MAP3K5, and FOXO3 through phosphorylation. PIM1 Protein, Human is the recombinant human-derived PIM1 protein, expressed by E. coli , with tag free. The total length of PIM1 Protein, Human is 300 a.a., .
SpeciesSummary :
Human
Background :
The PIM1 protein, a proto-oncogene with serine/threonine kinase activity, plays a pivotal role in cell survival and proliferation, conferring a selective advantage in tumorigenesis. Its oncogenic activity involves the regulation of MYC transcriptional activity, cell cycle progression, and phosphorylation-mediated inhibition of proapoptotic proteins, including BAD, MAP3K5, and FOXO3. PIM1 phosphorylates MYC, enhancing its stability and transcriptional activity, potentially explaining the synergism between PIM1 and MYC in tumorigenesis. By phosphorylating BAD, PIM1 induces the release of the anti-apoptotic protein Bcl-X(L)/BCL2L1, promoting survival signaling. Additionally, PIM1 phosphorylates MAP3K5, inhibiting its kinase activity and suppressing MAP3K5-mediated apoptotic signaling. PIM1 stimulates cell cycle progression at G1-S and G2-M transitions by phosphorylating CDC25A and CDC25C, and it down-regulates the cell cycle regulator CDKN1B at both transcriptional and post-translational levels. PIM1 also impacts chromatin structure by phosphorylating HP1 gamma/CBX3 and acts as a regulator of homing and migration of bone marrow cells. Furthermore, PIM1 positively regulates mTORC1 signaling, inhibits drug sensitivity through ABCG2 phosphorylation and activation, and promotes brown adipocyte differentiation.
ALTnames :
PIM1; Serine/threonine-protein kinase pim-1
Purity :
Greater than 90% as determined by reducing SDS-PAGE.
Buffer :
Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 20% glycerol, 1 mM DTT, pH 7.5.
Storage :
Shipping with dry ice
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA