protein

PIK3R3 Protein, Human (Sf9, His, GST)

HY-P701744

10 μg;50 μg

300;800 USD

PIK3R3 Protein, Human (Sf9, His, GST)

proteins

Sf9 insect cells

10 μg;50 μg

300;800 USD

PIK3R3 protein, through its SH2 domain, interacts with phosphorylated protein-tyrosine kinases, crucially regulating their kinase activity. During insulin stimulation, PIK3R3 binds to IRS-1. Operating as a heterodimer with a p110 catalytic subunit, it interacts with AXL, expanding its functional network. PIK3R3 Protein, Human (Sf9, His, GST) is the recombinant human-derived PIK3R3 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of PIK3R3 Protein, Human (Sf9, His, GST) is 460 a.a., .

Human

The PIK3R3 protein engages with activated (phosphorylated) protein-tyrosine kinases via its SH2 domain, playing a pivotal role in modulating their kinase activity. Additionally, during insulin stimulation, PIK3R3 forms a binding association with IRS-1. This protein operates as a heterodimer, comprising a regulatory subunit (PIK3R3) and a p110 catalytic subunit (PIK3CA, PIK3CB, or PIK3CD). Furthermore, PIK3R3 demonstrates interaction with AXL, contributing to its functional network.

PIK3R3; Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3K regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5% glycerol, 1 mM DTT, 0.1 M Trehalose.

Shipping with dry ice