protein

PAK6 Protein, Human

HY-P701732

10 μg;50 μg

245;690 USD

PAK6 Protein, Human

proteins

E. coli

10 μg;50 μg

245;690 USD

PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human is the recombinant human-derived PAK6 protein, expressed by E. coli , with tag free. The total length of PAK6 Protein, Human is 292 a.a., .

Human

PAK6, a serine/threonine protein kinase, serves as a regulator of gene transcription, with its kinase activity triggered by various effectors, including AR or MAP2K6/MAPKK6. Notably, it phosphorylates the DNA-binding domain of the androgen receptor/AR, hindering AR-mediated transcription, and also inhibits ESR1-mediated transcription. PAK6's involvement in cytoskeleton regulation is suggested by its interaction with IQGAP1. Additionally, PAK6 demonstrates a potential role in cell survival by protecting cells from apoptosis through the phosphorylation of BAD. This multifaceted kinase exhibits a regulatory impact on key cellular processes, showcasing its significance in transcriptional control and cytoskeletal dynamics.

PAK6; Serine/threonine-protein kinase PAK 6; PAK-5; p21-activated kinase 6; PAK-6

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl (pH 7.5), 500 mM NaCl, 10% glycerol, 1 mM DTT.

Shipping with dry ice