protein

HCK Protein, Human (Sf9, His)

HY-P701692

20 μg;50 μg;100 μg

420;800;1280 USD

HCK Protein, Human (Sf9, His)

proteins

Sf9 insect cells

20 μg;50 μg;100 μg

420;800;1280 USD

The HCK protein is a hematopoietic cell-dominated non-receptor tyrosine protein kinase that is critical for innate immune responses in neutrophils, monocytes, macrophages, and mast cells. HCK Protein, Human (Sf9, His) is the recombinant human-derived HCK protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of HCK Protein, Human (Sf9, His) is 446 a.a., .

Human

HCK Protein, a non-receptor tyrosine-protein kinase predominantly found in hematopoietic cells, serves as a pivotal mediator transmitting signals from various cell surface receptors and playing a crucial role in the regulation of innate immune responses. It intricately modulates functions in neutrophils, monocytes, macrophages, and mast cells, influencing processes such as phagocytosis, cell survival, proliferation, adhesion, and migration. Acting downstream of receptors including FCGR1A, FCGR2A, CSF3R, PLAUR, IFNG, IL2, IL6, IL8, and integrins ITGB1 and ITGB2, HCK orchestrates critical events during the phagocytic process, including mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase, leading to the respiratory burst and release of inflammatory molecules. Additionally, HCK promotes the reorganization of the actin cytoskeleton, actin polymerization, formation of podosomes, and cell protrusions. It inhibits TP73-mediated transcription activation and apoptosis while phosphorylating key signaling proteins such as CBL, ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1, and WAS, highlighting its extensive involvement in diverse cellular pathways.

HCK; Tyrosine-protein kinase HCK; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH7.5, 200 mM NaCl, 20% glycerol.

Shipping with dry ice