protein

DYRK1A Protein, Human

HY-P701667

10 μg;50 μg

235;650 USD

DYRK1A Protein, Human

proteins

E. coli

10 μg;50 μg

235;650 USD

DYRK1A protein has dual serine/threonine and tyrosine kinase activities. DYRK1A Protein, Human is the recombinant human-derived DYRK1A protein, expressed by E. coli , with tag free. The total length of DYRK1A Protein, Human is 359 a.a., .

Human

DYRK1A, a dual-specificity kinase endowed with both serine/threonine and tyrosine kinase activities, plays a pivotal role in various cellular processes. It exhibits a substrate preference for proline at position P+1 and arginine at position P-3, showcasing its specificity in substrate recognition. In the context of DNA damage response, DYRK1A emerges as a key participant in double-strand breaks repair, phosphorylating RNF169 to enhance its capability to impede TP53BP1 accumulation at DSB sites, thereby facilitating homologous recombination repair. Moreover, DYRK1A acts as a positive regulator of transcription by functioning as a CTD kinase, orchestrating the phosphorylation of the C-terminal domain of the large subunit of RNA polymerase II (POLR2A). This kinase may contribute to a signaling pathway governing nuclear functions related to cell proliferation and modulates alternative splicing through the phosphorylation of the splice factor SRSF6. With pro-survival functions, DYRK1A negatively regulates apoptosis, promoting cell survival under genotoxic stress by phosphorylating SIRT1, consequently inhibiting p53/TP53 activity. Additionally, DYRK1A targets SEPTIN4, SEPTIN5, and SF3B1 for phosphorylation at 'Thr-434,' further expanding its regulatory repertoire.

DYRK1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog; MNBH; hMNB

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 20mM HEPES (pH 7.5), 150 mM NaCl, 1mM TCEP.

Shipping with dry ice