protein

AMSH-LP Protein, Human

HY-P701477

10 μg;50 μg

250;685 USD

AMSH-LP Protein, Human

proteins

E. coli

10 μg;50 μg

250;685 USD

AMSH-LP is a zinc metalloprotease that selectively cleaves "Lys-63" linked polyubiquitin chains and acts as a positive regulator of the TORC1 signaling pathway. It specifically deubiquitinates SESN2, disrupts its interaction with the GATOR2 complex and inhibits SESN2-mediated regulation of TORC1. AMSH-LP Protein, Human is the recombinant human-derived AMSH-LP protein, expressed by E. coli , with tag free.

Human

AMSH-LP (AMSHLP), a zinc metalloprotease, exhibits a selective ability to cleave 'Lys-63'-linked polyubiquitin chains, without affecting 'Lys-48'-linked polyubiquitin chains. Notably, AMSHLP serves as a positive regulator of the TORC1 signaling pathway through its role in the 'Lys-63'-linked deubiquitination of SESN2. This deubiquitination activity impedes the interaction between SESN2 and the GATOR2 complex, thereby contributing to the inhibition of SESN2-mediated TORC1 regulation. These functions underscore AMSHLP's specific involvement in fine-tuning cellular signaling pathways, particularly those associated with TORC1, through precise modulation of 'Lys-63'-linked polyubiquitin chains.

STAMBPL1; AMSH-like protease; AMSH-LP; STAM-binding protein-like 1

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 10 mM HEPES, 150 mM NaCl, 5% glycerol, pH 7.5.

Shipping with dry ice