protein

OTUD7B Protein, Human (Sf9, His, StreII)

HY-P701466

5 μg;10 μg;50 μg

100;170;520 USD

OTUD7B Protein, Human (Sf9, His, StreII)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg

100;170;520 USD

The OTUD7B protein acts as a negative regulator to inhibit the non-canonical NF-kappa-B pathway by deubiquitinating TRAF3, thereby inhibiting B cell responses. It prevents degradation of “Lys-48”-linked polyubiquitin chains on TRAF3 during atypical NF-kappa-B stimulation, avoiding overactivation of the pathway and affecting mucosal immunity. OTUD7B Protein, Human (Sf9, His, Strep) is the recombinant human-derived OTUD7B protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of OTUD7B Protein, Human (Sf9, His, Strep) is 842 a.a., .

Human

OTUD7B protein acts as a negative regulator of the non-canonical NF-kappa-B pathway by facilitating the deubiquitination of TRAF3, a suppressor of NF-kappa-B signaling, thereby dampening B-cell responses. In the context of non-canonical NF-kappa-B stimuli, OTUD7B targets 'Lys-48'-linked polyubiquitin chains on TRAF3, preventing its proteolysis and averting excessive activation of the non-canonical NF-kappa-B pathway. This negative regulatory role extends to mucosal immunity against infections. Additionally, OTUD7B modulates T cell receptor (TCR) signaling by deubiquitinating ZAP70, influencing NF-kappa-B activation in T cells. Furthermore, OTUD7B contributes to T cell homeostasis, playing a crucial role in normal T cell responses and the production of key cytokines such as IFNG and IL2. The protein also exhibits deubiquitinating activity towards EGFR and demonstrates versatility in hydrolyzing various polyubiquitin chain linkages, including 'Lys-11', 'Lys-48', and 'Lys-63'-linked polyubiquitin chains. While it exhibits a higher catalytic rate with 'Lys-11'-linked chains in vitro, the physiological significance of this preference remains uncertain.

OTUD7B; OTU domain-containing protein 7B; Cellular zinc finger anti-NF-kappa-B protein; Cezanne; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH7.5, 200 mM NaCl, 20% glycerol.

Shipping with dry ice