protein

USP22 Protein, Human (Sf9)

HY-P701443

10 μg;50 μg

340;950 USD

USP22 Protein, Human (Sf9)

proteins

Sf9 insect cells

10 μg;50 μg

340;950 USD

USP22 protein is a histone deubiquitinating enzyme in the SAGA complex that catalyzes the deubiquitination of histones H2A and H2B and acts as a coactivator. Activators such as MYC facilitate its recruitment to gene promoters, which is critical for transcriptional activation. USP22 Protein, Human (Sf9) is the recombinant human-derived USP22 protein, expressed by Sf9 insect cells , with tag free. The total length of USP22 Protein, Human (Sf9) is 524 a.a., .

Human

USP22 Protein serves as a histone deubiquitinating component within the transcription regulatory histone acetylation (HAT) complex SAGA. This enzyme plays a crucial role in catalyzing the deubiquitination of histones H2A and H2B, functioning as a coactivator in the process. Its recruitment to specific gene promoters is facilitated by activators such as MYC, and it proves essential for transcriptional activation. Additionally, USP22 is required for nuclear receptor-mediated transactivation and contributes to the regulation of cell cycle progression, highlighting its multifaceted involvement in key cellular processes. The dynamic interplay of USP22 within the SAGA complex underscores its significance in the orchestration of transcriptional events and cellular homeostasis.

USP22; Ubiquitin carboxyl-terminal hydrolase 22; Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 200 mM NaCl, 20% glycerol, 1 mM DTT.

Shipping with dry ice