protein

USP6 Protein, Human (Sf9, GST)

HY-P701429

10 μg;50 μg

335;940 USD

USP6 Protein, Human (Sf9, GST)

proteins

Sf9 insect cells

10 μg;50 μg

335;940 USD

USP6 protein is an ATP-independent isopeptidase with unique deubiquitinase activity that can cleave the C-terminus of ubiquitin and catalyze its own deubiquitination. Notably, it coordinates ARF6 plasma membrane localization and selectively affects ARF6-dependent endocytic protein trafficking. USP6 Protein, Human (Sf9, GST) is the recombinant human-derived USP6 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of USP6 Protein, Human (Sf9, GST) is 878 a.a., .

Human

USP6, an ATP-independent isopeptidase, possesses distinctive deubiquitinase activity, cleaving at the C-terminus of the ubiquitin moiety and catalyzing its own deubiquitination. In vitro, isoform 2 exhibits deubiquitinating activity, contrasting with isoform 3. Notably, USP6 plays a crucial role in orchestrating plasma membrane localization of ARF6 and selectively modulating ARF6-dependent endocytic protein trafficking. Its functional significance extends to tumorigenesis initiation, as it induces the production of matrix metalloproteinases through NF-kappa-B activation. USP6's multifaceted activity highlights its pivotal role in cellular processes, positioning it as a key player in protein regulation, membrane dynamics, and the intricate balance involved in tumorigenesis.

USP6; Ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinating enzyme 6; Proto-oncogene TRE-2; Ubiquitin thioesterase 6; Ubiquitin-specific-processing protease 6

Greater than 85% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 200 mM NaCl, 1 mM DTT, 20% glycerol.

Shipping with dry ice