protein

USP47 Protein, Human (Sf9, FLAG)

HY-P701421

20 μg;50 μg

350;790 USD

USP47 Protein, Human (Sf9, FLAG)

proteins

Sf9 insect cells

20 μg;50 μg

350;790 USD

The USP47 protein is a ubiquitin-specific protease that deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizes POLB, and regulates base excision repair (BER). In addition to DNA repair, USP47 is an important regulator of cell growth and genome integrity. USP47 Protein, Human (Sf9, FLAG) is the recombinant human-derived USP47 protein, expressed by Sf9 insect cells , with C-Flag labeled tag. The total length of USP47 Protein, Human (Sf9, FLAG) is 1374 a.a., .

Human

USP47 protein functions as a ubiquitin-specific protease with a specific role in the deubiquitination of monoubiquitinated DNA polymerase beta (POLB), thereby stabilizing POLB and contributing to the regulation of base-excision repair (BER). Beyond its role in DNA repair, USP47 emerges as a key regulator of cell growth and genome integrity. Additionally, it may exert its influence on cellular processes by indirectly modulating CDC25A expression at the transcriptional level, underscoring its multifaceted role in cellular homeostasis and genomic stability.

USP47; Ubiquitin carboxyl-terminal hydrolase 47; Deubiquitinating enzyme 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 20% glycerol, pH 7.5, 1 mM DTT.

Shipping with dry ice