protein

Spondin-2/SPON2 Protein, Human (HEK293, His)

HY-P70142

5 μg;10 μg;50 μg;100 μg;250 μg

50;85;255;400;750 USD

Spondin-2/SPON2 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;250 μg

50;85;255;400;750 USD

Spondin-2 protein is a matricellular protein with antigen binding, lipopolysaccharide binding and metal ion binding activity. Spondin-2 is essential for recruiting lymphocytes and initiating immune responses while being involved in cell adhesion, defense response to other organism; opsonization; and positive regulation of cytokine production. Spondin-2 is found to promote infiltration of M1-like macrophages and inhibits tumor metastasis in cancer research. Spondin-2/SPON2 Protein, Human (HEK293, His) is the recombinant human-derived Spondin-2/SPON2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Spondin-2/SPON2 Protein, Human (HEK293, His) is 305 a.a., with molecular weight of 38-42 kDa.

Human

Spondin-2 protein is a matricellular protein and a member of Mindin F-Spondin family with antigen binding, lipopolysaccharide binding and metal ion binding activity. Spondin-2 is essential for recruiting lymphocytes and initiating immune responses, represents a unique a pattern recognition molecule for microbial pathogens. Spondin-2 is involved in cell adhesion and act upstream of or within several processes, including defense response to other organism; opsonization; and positive regulation of cytokine production. Spondin-2 also functions as an integrin ligand for inflammatory cell recruitment and T-cell priming. The binding of bacteria by Spondin-2 promotes phagocytosis of the bacterium and stimulates the production of proinflammatory cytokines by the macrophage. Spondin-2 is found to promote infiltration of M1-like macrophages and inhibits tumor metastasis in cancer research [1] [2] [3] .

rHuSpondin-2/SPON2, His; Spondin-2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL-1; Mindin; SPON2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 1 mM EDTA, pH 7.4 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.