protein

USP46 Protein, Human

HY-P701419

10 μg;50 μg;100 μg

200;580;980 USD

USP46 Protein, Human

proteins

E. coli

10 μg;50 μg;100 μg

200;580;980 USD

USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human is the recombinant human-derived USP46 protein, expressed by E. coli , with tag free. The total length of USP46 Protein, Human is 366 a.a., .

Human

USP46 is identified as a behaviorally relevant deubiquitinating enzyme, potentially influencing behavior through the regulation of GABAergic neurotransmission. Its role is suggested to involve mediating the deubiquitination of GAD1/GAD67, crucial in GABA synthesis. Remarkably, USP46 exhibits minimal deubiquitinating activity independently, necessitating interaction with WDR48 for substantial enzymatic function. This intricate partnership with WDR48 highlights the collaborative nature of its enzymatic activity. Notably, USP46 does not participate in the deubiquitination of monoubiquitinated FANCD2, indicating specificity in its cellular functions.

USP46; Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 200 mM NaCl, 10% glycerol, 1 mM DTT.

Shipping with dry ice