protein

USP2 Protein, Human

HY-P701349

20 μg;50 μg

265;580 USD

USP2 Protein, Human

proteins

E. coli

20 μg;50 μg

265;580 USD

USP2 catalytic domain proteins act as hydrolases and target polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Both isoform 1 and isoform 4 exhibit ubiquitin-specific peptidase and isopeptidase activities. USP2 Protein, Human is the recombinant human-derived USP2 protein, expressed by E. coli , with tag free. The total length of USP2 Protein, Human is 347 a.a., .

Human

The USP2 catalytic domain protein acts as a hydrolase, targeting polyubiquitinated proteins such as MDM2, MDM4, and CCND1. Isoform 1 and isoform 4 exhibit both ubiquitin-specific peptidase and isopeptidase activities. Notably, it deubiquitinates MDM2, indirectly promoting p53/TP53 degradation and limiting p53 activity without reversing MDM2-mediated ubiquitination of p53. Additionally, USP2 prevents MDM2-mediated degradation of MDM4, contributing to the intricate regulation of cellular processes. In the context of cell-cycle progression, USP2 plays a role in G1/S transition in both normal and cancer cells. Furthermore, it emerges as a regulator of the circadian clock, influencing its intrinsic rhythm and responsiveness to external cues. By associating with clock proteins, USP2 deubiquitinates the core clock component PER1, affecting its nucleocytoplasmic shuttling and nuclear retention. This multifaceted protein also participates in the regulation of myogenic differentiation of embryonic muscle cells and serves as a circadian clock output effector, influencing Ca(2+) absorption in the small intestine by likely modulating NHERF4 levels and, consequently, the activity of the Ca(2+) channel TRPV6.

USP2; Ubiquitin carboxyl-terminal hydrolase 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, 500 mM NaCl, 5% glycerol, pH 8.0,

Shipping with dry ice