protein

FITC-labeled HER3 Protein, Human (HEK293, His)

HY-P701281

20 μg;50 μg;100 μg

260;500;800 USD

FITC-labeled HER3 Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

260;500;800 USD

HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. FITC-labeled HER3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled HER3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

Human

HER3, a tyrosine-protein kinase, serves as a critical cell surface receptor for neuregulins. Activated by neuregulin-1 (NRG1), ligand binding enhances phosphorylation on tyrosine residues and facilitates its interaction with the p85 subunit of phosphatidylinositol 3-kinase. Additionally, there is evidence suggesting activation by CSPG5. HER3 is intricately involved in the regulation of myeloid cell differentiation, highlighting its pivotal role in cellular processes crucial for normal development and function.

ERBB3; HER3; LCCS2; MDA-BF-1; MGC88033; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.