protein

RPRD1B Protein, Human (HEK293, N-His)

HY-P701252

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

52;88;247;420;1170;1980 USD

RPRD1B Protein, Human (HEK293, N-His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

52;88;247;420;1170;1980 USD

RPRD1B, is a necessary scaffolding protein that maintains genetic integrity by regulating resolution of R-loops at both the transcription termination and DNA double-strand break (DSB) repair levels. In endometrial cancers, RPRD1B accelerates cell cycle through up-regulating Cyclin D1, CDK4, and CDK6. In addition, RPRD1B enhancse transcription of CCND1 and promotes cell proliferation by interacting with RNA polymerase II. RPRD1B enhances the β-Catenin·TCF4 transcriptional activity in response to Wnt signaling [1] [2] [3] [4] . RPRD1B Protein, Human (HEK293, N-His) is the recombinant human-derived RPRD1B protein, expressed by HEK293 , with N-6*His labeled tag.

Human

RPRD1B, also known as Ku70-binding protein 5-Hera or CREPT, is a necessary scaffolding protein that maintains genetic integrity by regulating resolution of R-loops at both the transcription termination and DNA double-strand break (DSB) repair levels [1] . RPRD1B is upregulated in various cancers and regulates genome stability and transcription termination [2] . In endometrial cancers, RPRD1B accelerates cell cycle through up-regulating Cyclin D1, CDK4, and CDK6 (main regulators of the G1/S phase transition during cell cycle) [3] . In addition, RPRD1B enhancse transcription of CCND1 and promotes cell proliferation by interacting with RNA polymerase II. RPRD1B enhances the β-Catenin·TCF4 transcriptional activity in response to Wnt signaling [4] .

Regulation of nuclear pre-mRNA domain-containing protein 1B; C20orf77; CREPT

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.