protein

IGF-I Protein, Salmon

HY-P701241

10 μg;50 μg

135;380 USD

IGF-I Protein, Salmon

proteins

E. coli

10 μg;50 μg

135;380 USD

IGF-I protein is similar to insulin and exerts effective growth-promoting activity as a ligand of IGF1R. Binding to the α subunit of IGF1R activates intrinsic tyrosine kinase, triggering autophosphorylation of the β subunit. IGF-I Protein, Salmon is the recombinant IGF-I protein, expressed by E. coli , with tag free. The total length of IGF-I Protein, Salmon is 70 a.a., with molecular weight of ~8 kDa.

Others

The IGF-I protein, structurally and functionally related to insulin, exhibits significantly higher growth-promoting activity. Serving as a ligand for IGF1R, it binds to the alpha subunit of IGF1R, triggering the activation of the intrinsic tyrosine kinase activity. This activation leads to the autophosphorylation of tyrosine residues in the beta subunit, initiating a cascade of downstream signaling events that activate the PI3K-AKT/PKB and Ras-MAPK pathways. IGF-I also binds to integrins, forming a ternary complex with integrins and IGFR1, which proves essential for IGF1 signaling. This intricate molecular interaction highlights the multifaceted role of IGF-I in mediating cellular responses and growth-promoting functions.

IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.