protein

HNRNPM Protein, Human (N-His)

HY-P701226

5 μg;10 μg;50 μg

59;100;280 USD

HNRNPM Protein, Human (N-His)

proteins

E. coli

5 μg;10 μg;50 μg

59;100;280 USD

The HNRNPM protein is a key pre-mRNA binding protein that exhibits strong affinity for poly(G) and poly(U) RNA homopolymers. It is central to the splicing process, complexly regulates RNA maturation, and serves as a receptor for carcinoembryonic antigen in Kupffer cells. HNRNPM Protein, Human (N-His) is the recombinant human-derived HNRPM protein, expressed by E. coli , with N-10*His labeled tag.

Human

The HNRNPM protein emerges as a crucial pre-mRNA binding protein in vivo, exhibiting a strong affinity for poly(G) and poly(U) RNA homopolymers in vitro. Functionally implicated in splicing processes, HNRNPM plays a significant role in the intricate regulation of RNA maturation. Beyond its involvement in splicing, it acts as a receptor for carcinoembryonic antigen in Kupffer cells, potentially initiating a cascade of signaling events leading to the tyrosine phosphorylation of proteins and the induction of cytokines such as IL-1 alpha, IL-6, IL-10, and tumor necrosis factor alpha. Notably, HNRNPM is identified as a component of the spliceosome C complex, underscoring its association with fundamental RNA processing machinery. Moreover, the protein interacts with PPIA/CYPA, further expanding its network of molecular interactions and highlighting its multifaceted role in cellular processes.

CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from sterile 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol.

Room temperature in continental US; may vary elsewhere.