protein

HNF4A Protein, Human (His, solution)

HY-P701139

50 μg

250 USD

HNF4A Protein, Human (His, solution)

proteins

HEK293

50 μg

250 USD

HNF 4 alpha, a nuclear transcription factor, forms homodimers to bind DNA. It regulates gene expression, including hepatocyte nuclear factor 1 alpha, impacting hepatic genes. Its involvement extends to liver, kidney, and intestinal development. Mutations associate with autosomal dominant non-insulin-dependent diabetes mellitus type I. The gene exhibits biased expression in the duodenum (RPKM 37.7) and colon (RPKM 32.8), among other tissues. HNF4A Protein, Human (His, solution) is the recombinant human-derived HNF 4 alpha, expressed by HEK293 , with C-10*His labeled tag.

Human

HNF 4 alpha, the protein product of this gene, functions as a nuclear transcription factor, forming homodimers to bind DNA and exerting control over the expression of various genes, including hepatocyte nuclear factor 1 alpha, a key regulator of hepatic gene expression. Its involvement extends to the development of vital organs such as the liver, kidney, and intestines. Mutations in HNF 4 alpha have been linked to monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I, underscoring its significance in metabolic regulation. Additionally, alternative splicing yields multiple transcript variants, generating diverse isoforms. Notably, HNF 4 alpha displays biased expression, with higher levels observed in the duodenum (RPKM 37.7), colon (RPKM 32.8), and seven other tissues, emphasizing its specialized role in diverse physiological contexts.

FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF-14; TCF14

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 10% glycerol, pH 7.3.

Shipping with dry ice