protein

alpha Actinin 4/ACTN4 Protein, Human (HEK293, C-His)

HY-P701113

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

84;140;400;680;1200;1600 USD

alpha Actinin 4/ACTN4 Protein, Human (HEK293, C-His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

84;140;400;680;1200;1600 USD

Alpha-actinin 4 is a member of the spectrin gene superfamily and binds to actin in a variety of cell types. It localizes to microfilament bundles, adherens junctions, and Z-disks, promoting actin binding to membranes. alpha Actinin 4 (ACTN4) Protein,Human (HEK293,C-His) is the recombinant human-derived alpha Actinin 4, expressed by HEK293 , with C-10*His labeled tag. The total length of alpha Actinin 4 (ACTN4) Protein,Human (HEK293,C-His) is 911 a.a., with molecular weight of ~106-120 kDa.

Human

Alpha Actinin 4, a member of the spectrin gene superfamily, plays a multifaceted role as an actin-binding protein in various cell types. The nonmuscle isoform is distributed along microfilament bundles and adherens-type junctions, facilitating actin-membrane binding in nonmuscle cells. Conversely, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, anchoring myofibrillar actin filaments. In the cytoplasm, this gene encodes a nonmuscle alpha actinin isoform, believed to be involved in metastatic processes. Notably, mutations in this gene have been linked to focal and segmental glomerulosclerosis, highlighting its significance in both cellular architecture and disease pathology. With ubiquitous expression observed in tissues such as placenta (RPKM 105.3), kidney (RPKM 104.8), and 25 other tissues, Alpha Actinin 4 emerges as a critical player in cellular dynamics and disease-associated mechanisms.

ACTININ-4; FSGS; FSGS1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.