protein

Intelectin-1/ITLN1 Protein, Human (N-His, C-myc)

HY-P701099

20 μg;50 μg;100 μg

150;280;450 USD

Intelectin-1/ITLN1 Protein, Human (N-His, C-myc)

proteins

E. coli

20 μg;50 μg;100 μg

150;280;450 USD

Intelectin-1/ITLN1 is a lectin with specific affinity for microbial carbohydrate chains and recognizes β-linked D-galactofuranosose, D-glycerolphosphate modified glycans, D-glycerol-D-talo-oct- 2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-keto acid (KDO). It binds to bacterial glycans and helps defend against microorganisms. Intelectin-1/ITLN1 Protein, Human (N-His, C-myc) is the recombinant human-derived Intelectin-1/ITLN1 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Intelectin-1/ITLN1 Protein, Human (N-His, C-myc) is 280 a.a., with molecular weight of ~38.6 kDa.

Human

The Intelectin-1/ITLN1 protein operates as a lectin with a specific affinity for microbial carbohydrate chains in a calcium-dependent manner. It recognizes microbial glycans containing a terminal acyclic 1,2-diol moiety, such as beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO), and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). This lectin binds to glycans found in both Gram-positive and Gram-negative bacteria, including K. pneumoniae, S. pneumoniae, Y. pestis, P. mirabilis, and P. vulgaris, while showing no affinity for human glycans. Likely contributing to the defense system against microorganisms, Intelectin-1/ITLN1 may function as an adipokine with a potential role in glucose uptake regulation and insulin-stimulated glucose uptake in adipocytes. It enhances AKT phosphorylation, both in the absence and presence of insulin. Additionally, Intelectin-1/ITLN1 may interact with lactoferrin/LTF, increasing its uptake and potentially playing a role in iron absorption. The protein forms homotrimers through disulfide linkages and may interact with lactoferrin/LTF.

ITLN1; intelectin 1 (galactofuranose binding); intelectin-1; FLJ20022; hIntL; HL 1; ITLN; LFR; ITLN-1; endothelial lectin HL-1; galactofuranose-binding lectin; intestinal lactoferrin receptor; HL1; HL-1; INTL; omentin;

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.