protein

IFN-alpha 2b/IFNA2 Protein, Human (His)

HY-P701095

2 μg;10 μg;50 μg;100 μg

35;60;120;190 USD

IFN-alpha 2b/IFNA2 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

35;60;120;190 USD

IFN-alpha 2 (IFNA2), belongs to type I interferon family, is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection [1] . IFN-alpha 2 exerts cytotoxic activity against CD8 + T cells and induces CD4 + T cell depletion [3] . IFN-alpha 2b/IFNA2 Protein, Human contains 165 a.a., is produced in E. coli with N-6*His tagged.

Human

IFN-alpha 2 (IFNA2; IFN-α2), belongs to the type I interferon family, produced by the plasmacytoid dendritic cells (pDCs) exposure to HIV-1BaL in order to inhibit viral infection [1] . Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively [2] . IFN-alpha 2 subtype is the only one that is currently licensed to treat infections caused by hepatitis B virus (HBV) and HCV [3] . IFN-alpha 2 shows a Sortilin-dependent trafficking in cells and increases the expression level of interferon-stimulated genes (ISGs) in HIV-infected cells [1] [4] . It also exhibits cytotoxic activity against CD8 + T cells and enhances CD4 + T cell depletion [3] . Among the IFN-alpha 2 alleles, IFN-alpha 2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant [5] . IFN-alpha 2 has a bored application in research of cancer, including some hematological malignancies and solid tumors [6] . As for a wildly use of IFN in animal disease model, the sequence of amino acids in IFNA2a protein of human is very different from mouse (59.57%).

rHuIFN-α2b; IFNA; IFNA2; IFN-a 2b

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.