protein

Neogenin Protein, Human (HEK293, hFc)

HY-P701081

20 μg;50 μg;100 μg

180;345;550 USD

Neogenin Protein, Human (HEK293, hFc)

proteins

HEK293

20 μg;50 μg;100 μg

180;345;550 USD

Neogenin is a multifunctional cell surface receptor that controls multiple developmental processes by regulating cell adhesion. It affects neural tube and mammary gland formation, myogenesis and angiogenesis. Neogenin Protein, Human (HEK293, hFc) is the recombinant human-derived Neogenin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Neogenin Protein, Human (HEK293, hFc) is 1072 a.a., with molecular weight of 150-180 kDa.

Human

Neogenin, a versatile cell surface receptor, orchestrates diverse developmental processes by regulating cell adhesion. Its influence spans neural tube and mammary gland formation, myogenesis, and angiogenesis. Functioning as a receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families, Neogenin engages in complex interactions pivotal to cellular responses. Notably, interactions with netrin lead to chemoattractive axon guidance responses and cell-cell adhesion, while engagements with RGMa and RGMb induce chemorepulsive responses. The receptor also interacts with MYO10 and forms associations with specific BMPs, including BMP2, BMP4, BMP6, and BMP7. This comprehensive network of interactions underscores Neogenin's central role in regulating cell adhesion across a spectrum of crucial developmental contexts.

NEO1; IGDCC2; NGN; NEO; neogenin 1;

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.