protein

DMP-1 Protein, Human (HEK293, His)

HY-P70105

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

30;45;120;200;500;700 USD

DMP-1 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

30;45;120;200;500;700 USD

DMP-1 protein exhibits dual functions in osteoblast differentiation. In undifferentiated osteoblast nuclei, its nonphosphorylated form activates osteoblast-specific genes. DMP-1 Protein, Human (HEK293, His) is the recombinant human-derived DMP-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DMP-1 Protein, Human (HEK293, His) is 497 a.a., with molecular weight of 53-90 kDa.

Human

DMP-1 Protein appears to exhibit a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, its unphosphorylated form functions as a transcriptional component, activating osteoblast-specific genes such as osteocalcin. As osteoblasts transition to osteocytes, DMP-1 undergoes phosphorylation and is subsequently exported into the extracellular matrix. In this extracellular environment, it plays a regulatory role in the nucleation of hydroxyapatite, suggesting its involvement in the mineralization process. DMP-1's intricate functions underscore its significance in the molecular events that govern osteoblast differentiation and bone formation. Notably, DMP-1 interacts with importin alpha, adding a layer of complexity to its cellular dynamics and potential regulatory mechanisms.

rHuDentin matrix acidic phosphoprotein 1/DMP-1, His; Dentin Matrix Acidic Phosphoprotein 1; DMP-1; Dentin Matrix Protein 1; DMP1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Histidine-HCl, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 6.0 or PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.