protein

TWEAK/TNFSF12 Protein, Human (HEK293, hFc)

HY-P701045

20 μg;50 μg

150;320 USD

TWEAK/TNFSF12 Protein, Human (HEK293, hFc)

proteins

HEK293

20 μg;50 μg

150;320 USD

TWEAK/TNFSF12 Protein binds to FN14 and potentially TNRFSF12/APO3, weakly inducing apoptosis in certain cells. It activates NF-kappa-B, enhances angiogenesis, and stimulates endothelial cell proliferation. Furthermore, TWEAK/TNFSF12 is implicated in inflammatory cytokine induction and promotes IL8 secretion. It forms a homotrimer and interacts with the angiogenic factor AGGF1/VG5Q. TWEAK/TNFSF12 Protein, Human (HEK293, hFc) is the recombinant human-derived TWEAK/TNFSF12 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TWEAK/TNFSF12 Protein, Human (HEK293, hFc) is 207 a.a., with molecular weight of 50-60 kDa.

Human

The TWEAK/TNFSF12 Protein exhibits binding affinity for FN14 and potentially TNRFSF12/APO3, functioning as a weak inducer of apoptosis in certain cell types. Additionally, TWEAK/TNFSF12 is involved in NF-kappa-B activation, thereby mediating multiple cellular responses, including angiogenesis and the proliferation of endothelial cells. Its role extends to the induction of inflammatory cytokines and the promotion of IL8 secretion. As a homotrimer, TWEAK/TNFSF12 likely engages in intricate molecular interactions to orchestrate its diverse functions. Furthermore, it interacts with the angiogenic factor AGGF1/VG5Q, further underscoring its involvement in angiogenesis and its potential as a regulator of cellular processes with implications for inflammation and vascular homeostasis.

APO3 ligand; APO3L; DR3LG; UNQ181/PRO207; TWEAK; MGC129581

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.