protein

MDK/Midkine Protein, Mouse (His)

HY-P701025

20 μg;50 μg

160;320 USD

MDK/Midkine Protein, Mouse (His)

proteins

E. coli

20 μg;50 μg

160;320 USD

Midkine (MDK) is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors.It affects inflammatory responses, cell proliferation, adhesion, survival, tissue regeneration, differentiation and migration.MDK/Midkine Protein, Mouse (His) is the recombinant mouse-derived MDK/Midkine protein, expressed by E.coli , with N-His labeled tag.

Mouse

Midkine (MDK) is a secreted protein functioning as a versatile cytokine and growth factor, transmitting signals through both cell-surface proteoglycan and non-proteoglycan receptors. It engages in diverse cellular processes, such as inflammatory response, cell proliferation, adhesion, survival, tissue regeneration, differentiation, and migration. MDK plays a pivotal role in inflammatory processes by orchestrating the recruitment of neutrophils and macrophages to inflammation sites, exhibiting dual activities that include promoting epithelial cell survival and facilitating smooth muscle cell migration following renal and vessel damage. Moreover, MDK suppresses tolerogenic dendritic cell development, inhibiting regulatory T cell differentiation, and fosters T cell expansion through NFAT signaling, influencing Th1 cell differentiation. The protein's involvement extends to tissue regeneration, contributing to heart damage recovery by negatively regulating inflammatory cell recruitment and mediating cell survival through MAPKs and AKT pathways. Additionally, MDK facilitates liver regeneration, bone repair, and brain development, promoting neural precursor cell survival, neurite outgrowth, and embryonic neurons' survival. Its interactions with various receptors, such as PTPRZ1, ITGA4:ITGB1 complex, LRP1, and GPC2, underscore MDK's intricate regulatory role in diverse physiological processes.

MK; ARAP; MDK; MEK; MK1; MKARAP; NEGF2

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.22μm filtered solution of PBS, 350mM NaCl, 200mM L-Arginine, pH 7.4.

Shipping with dry ice