protein

IL-12 Protein, Cynomolgus (HEK293, His)

HY-P701008

2 μg;10 μg;20 μg;50 μg;100 μg

32;82;130;250;400 USD

IL-12 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

2 μg;10 μg;20 μg;50 μg;100 μg

32;82;130;250;400 USD

IL-12 protein forms a heterodimer with IL23A to produce the cytokine IL-23, which is critical in innate and adaptive immunity. IL-23 works synergistically with IL-17 to promote the acute response of peripheral tissues to infection. IL-12 Protein, Cynomolgus (HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived IL-12 protein, expressed by HEK293 , with C-His labeled tag. IL-12 Protein, Cynomolgus (HEK293, His), has molecular weight of 45-48 kDa (IL-12B) & 38-44 kDa (IL-12A), respectively.

Cynomolgus

The IL-12 Protein forms a heterodimer with IL23A, resulting in the creation of the IL-23 interleukin, a cytokine with diverse functions in innate and adaptive immunity. In collaboration with IL-17, IL-23 may orchestrate an acute response to infection in peripheral tissues. Binding to a heterodimeric receptor complex composed of IL12RB1 and IL23R, IL-23 activates the Jak-Stat signaling cascade, preferentially stimulates memory T-cells over naive T-cells, and facilitates the production of pro-inflammatory cytokines. Furthermore, IL-23 has been implicated in inducing autoimmune inflammation, potentially playing a role in autoimmune inflammatory diseases and tumorigenesis. This cytokine acts as a growth factor for activated T and NK cells, enhances the lytic activity of NK/lymphokine-activated killer cells, and stimulates the production of IFN-gamma by resting PBMC.

CLMF; CLMF2; IL-12A; IL-12B; IL12; IL12 p70; IMD28; IMD29; NFSK; NKSF1; NKSF2; P35; IL-12 subunit p35; IL12A; interleukin 12

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.