protein

IFN-gamma Protein, Cynomolgus (HEK293, His)

HY-P701006

20 μg;50 μg

174;382 USD

IFN-gamma Protein, Cynomolgus (HEK293, His)

proteins

HEK293

20 μg;50 μg

174;382 USD

IFN-gamma (interferon-gamma) is a type II interferon derived from immune cells such as T cells and NK cells, which can significantly activate effector immune cells and enhance antigen presentation. It affects gene regulation through the JAK-STAT pathway and its receptor IFNGR1. IFN-gamma Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IFN-gamma protein, expressed by HEK293 , with C-His labeled tag. The total length of IFN-gamma Protein, Cynomolgus (HEK293, His) is 142 a.a., with molecular weight of 25-35 kDa.

Cynomolgus

IFN-gamma (Interferon-gamma), a type II interferon produced by immune cells like T-cells and NK cells, plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Its primary signaling pathway involves the JAK-STAT pathway after interaction with its receptor, IFNGR1, affecting gene regulation. Upon IFN-gamma binding, the IFNGR1 intracellular domain opens out, allowing the association of downstream signaling components JAK2, JAK1, and STAT1, resulting in STAT1 activation, nuclear translocation, and transcription of IFN-gamma-regulated genes. Many of these induced genes are transcription factors such as IRF1, capable of further driving the regulation of a subsequent wave of transcription. IFN-gamma contributes to the class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits, thereby increasing the quantity, quality, and repertoire of peptides for class I MHC loading. It also enhances the efficiency of peptide generation by inducing the expression of the activator PA28, which associates with the proteasome and alters its proteolytic cleavage preference. Additionally, IFN-gamma up-regulates MHC II complexes on the cell surface by promoting the expression of key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Beyond its direct immune functions, IFN-gamma participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions, influencing their development, quiescence, and differentiation. Existing as a homodimer, IFN-gamma interacts with IFNGR1 via its extracellular domain; this interaction is pivotal in promoting IFNGR1 dimerization and orchestrating the diverse and critical functions of IFN-gamma in immune responses and hematopoiesis.

IFN-gamma-R1; CDw119; CD119; IFNGR1; IFNGR; AVP; FLJ45734; IFN-gamma R1; IFN-gR1; type 2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.