Galectin-3/LGALS3 Protein, Cynomolgus (HEK293, His) | MedChem Express LLC HY-P700996 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

Galectin-3/LGALS3 Protein, Cynomolgus (HEK293, His)

catalog :

HY-P700996

quantity :

20 μg;50 μg;100 μg

price :

214;406;650 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P700996

Product Name :

Galectin-3/LGALS3 Protein, Cynomolgus (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

20 μg;50 μg;100 μg

List Price :

214;406;650 USD

Product Description :

The Galectin-3/LGALS3 protein is a galactose-specific lectin known for its diverse roles in cellular processes. It binds IgE and synergizes with α-3 and β-1 integrins to promote CSPG4-induced endothelial cell migration. Galectin-3/LGALS3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Galectin-3/LGALS3 protein, expressed by HEK293 , with N-His labeled tag.

SpeciesSummary :

Cynomolgus

Background :

The Galectin-3/LGALS3 Protein is a galactose-specific lectin known for its versatile roles in cellular processes. It binds IgE and, in collaboration with the alpha-3, beta-1 integrin, facilitates CSPG4-induced migration of endothelial cells. Together with DMBT1, it is crucial for the terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus, the protein serves as a pre-mRNA splicing factor and is actively involved in acute inflammatory responses, influencing neutrophil activation, adhesion, chemoattraction of monocytes and macrophages, opsonization of apoptotic neutrophils, and mast cell activation. Its partnership with TRIM16 allows for the coordinated recognition of membrane damage, triggering the mobilization of core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. The protein likely forms homo- or heterodimers and engages with various partners, including DMBT1, CD6, ALCAM, ITGA3, ITGB1, CSPG4, LGALS3BP, LYPD3, ZFTRAF1, UACA, TRIM16, and TMED10, facilitating diverse cellular interactions, including autophagy and secretion.

ALTnames :

AGE-R3; CBP35; GAL3; Gal-3; galactin-3; GALBPCBP35; Galectin3; GALIG; L29; L31; Lectin L-29; LGALS2; LGALS3; Mac-2; MAC2GAL3

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Buffer :

Lyophilized from a 0.22 μm filtered solution of 50 mM Hepes, 150 mM NaCl, 200 mM L-Arginine, 2 mM Tcep, pH 6.5.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage