protein

Copine-1/CPNE1 Protein, Human (His)

HY-P70097

10 μg;50 μg

104;314 USD

Copine-1/CPNE1 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

104;314 USD

Copine-1/CPNE1 protein is a calcium-dependent phospholipid-binding protein that participates in the TNF-α receptor signaling pathway in a calcium-dependent manner. CPNE1 induces AKT-dependent neurite outgrowth and is also involved in TNF-α-induced repression of NF-κ-B transcription. Copine-1/CPNE1 Protein, Human (His) is the recombinant human-derived Copine-1/CPNE1 protein, expressed by E. coli , with N-6*His, C-6*His labeled tag. The total length of Copine-1/CPNE1 Protein, Human (His) is 537 a.a., with molecular weight of 58-66 kDa.

Human

Copine-1, also known as CPNE1, is a calcium-dependent phospholipid-binding protein that actively participates in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway, Copine-1 exhibits calcium-dependent phospholipid binding properties. Additionally, it plays a pivotal role in neuronal progenitor cell differentiation by inducing neurite outgrowth through an AKT-dependent signaling cascade, operating in a calcium-independent manner. Copine-1 may also contribute to the recruitment of target proteins to the cell membrane in a calcium-dependent fashion and is implicated in membrane trafficking. Furthermore, it is involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of various NF-kappa-B subunits, including p65/RELA, p50/NFKB1, p52/NFKB2, RELB, and REL. The multifaceted functions of Copine-1 highlight its versatile role in cellular processes, ranging from neuronal development to membrane dynamics and signal transduction pathways.

rHuCopine-1/CPNE1, His; Copine-1; Copine I; CPN1; CPNE1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB，150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.