protein

CA125 Protein, Human (685a.a, HEK293, His)

HY-P700961

20 μg;50 μg;100 μg

150;300;500 USD

CA125 Protein, Human (685a.a, HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

150;300;500 USD

The CA125 protein acts by binding to MSLN and plays a crucial role in forming a protective and lubricating barrier on mucosal surfaces. This interaction promotes heterotypic cell adhesion and is suggested to play an important role in peritoneal metastasis of ovarian cancer. CA125 Protein, Human (685a.a, HEK293, His) is the recombinant human-derived CA125 protein, expressed by HEK293 , with C-His labeled tag. The total length of CA125 Protein, Human (685a.a, HEK293, His) is 685 a.a., with molecular weight of 90-140 kDa.

Human

CA125 protein is believed to serve a crucial role in establishing a protective and lubricating barrier against particles and infectious agents at mucosal surfaces. It exerts its functions through binding to MSLN, where the interaction mediates heterotypic cell adhesion. This adhesive property may play a significant role in the metastasis of ovarian cancer to the peritoneum, as CA125 initiates cell attachment to the mesothelial epithelium by binding to MSLN. The interaction between CA125 and MSLN underscores its potential involvement in the adhesive events associated with cancer metastasis, particularly in the context of ovarian cancer progression to the peritoneal cavity.

CA125; CA-125; CA125MUC-16; FLJ14303; MUC16

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.