protein

DCBLD2 Protein, Human (HEK293, His)

HY-P70095

10 μg;50 μg

55;150 USD

DCBLD2 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

55;150 USD

DCBLD2 Protein is a novel platelet membrane receptor that recruits TRAF6 through EGFR phosphorylation and stimulates AKT to promote tumorigenesis. The DCBLD2 Protein has multiple functions during development as well as in vascular and tumor biology, such as influencing cell proliferation and tumorigenesis. DCBLD2 Protein, Human (HEK293, His) is the recombinant human-derived DCBLD2 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

DCBLD2 encodes discoid, CUB, and LCCL domain protein 2, also known as endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) and/or Charcot-Leyden crystalloprotein pseudogene 1 (CLCP1). The DCBLD2 gene is a type I transmembrane receptor that has structural similarities to neuropilin-like transmembrane scaffold receptors, such as vascular endothelial growth factor (VEGF) receptors and signaling proteins, and has multiple functions in developmental processes as well as in vascular and tumor biology. DCBLD2 is a novel platelet membrane receptor that plays a key role in vascular remodeling, influencing vascular smooth muscle cell (VSMC) proliferation, cell movement and metastasis in some cancers, and neuronal localization. DCBLD2 recruits TRAF6 through EGFR phosphorylation and stimulates AKT to promote tumorigenesis [1] [2] [3] [4] [5] .

rHuDiscoidin, CUB and LCCL domain-containing protein 2/ DCBLD2, His; Discoidin; CUB and LCCL domain-containing protein 2; DCBLD2; CUB; LCCL and coagulation factor V/VIII-homology domains protein 1; Endothelial and smooth muscle cell-derived neuropilin-like protein; DCBLD2; CLCP1; ESDN;

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.